Armed
Ready for the next cancer
A cycle starts on its own. Evidence first, then the challenger, then four gates.
- 00Pack
- 01Enter
- 02Triage
- 03Mechanism
- 04Tractability
- 05Falsification
- 06Ledger
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Pancreatic ductal adenocarcinoma
[KNOWN] PDAC has poor survival, dense cancer-associated stroma, limited baseline T-cell infiltration, and frequent KRAS pathway dependence. [KNOWN] The evidence pack supports personalized RNA neoantigen vaccination as an active research direction but provides no validated target list or trial readouts. [INFERRED] The most testable portfolio should combine established cytotoxic backbones with genotype-selected KRAS strategies, immune priming, and deliberately risky stromal or immunotherapy hypotheses.
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